Predominance of rhinovirus in the nose of symptomatic and asymptomatic infants
Identifieur interne : 001859 ( Main/Exploration ); précédent : 001858; suivant : 001860Predominance of rhinovirus in the nose of symptomatic and asymptomatic infants
Auteurs : Inesz Van Benten ; Laurens Koopman ; Bert Niesters ; Wim Hop [Pays-Bas] ; Barbara Van Middelkoop ; Leon De Waal ; Kees Van Drunen ; Albert Osterhaus ; Herman Neijens ; Wytske FokkensSource :
- Pediatric Allergy and Immunology [ 0905-6157 ] ; 2003-10.
English descriptors
- Teeft :
- Allergic, Allergic disease, Allergy, Asthma, Atopy, Bronchiolitis, Clin, Clin microbiol, Clinical symptoms, Cohort, Coronavirus, Cytokine, Cytokine production, Environmental factors, Epidemiological studies, Family history, General malaise, Higher prevalence, Immune, Immune response, Immune system, Infant, Infection, Logistic regression, Nasal, Nasal symptoms, Other children, Parental history, Pathogen, Physical examination, Prevalence, Respir crit care, Respiratory syncytial virus, Respiratory viruses, Rhinitis, Rhinitis group, Rhinorrhoea, Rhinorrhoea episodes, Rhinovirus, Rhinovirus infection, Rhinovirus infections, Rhinovirus prevalence, Routine visits, Sibling, Sick visits, Symptom, Syncytial, Tract disease, Tract infection, Tract infections, Urti, Urti group, Viral, Viral infection, Viral infections, Virus infections.
Abstract
Respiratory infections in infancy may protect against developing Th2‐mediated allergic disease (hygiene hypothesis). To estimate the relative contribution of particular viruses to the development of the immune system and allergic disease, we investigated longitudinally the prevalence of respiratory viral infections in infants. One hundred and twenty‐six healthy infants were included in this prospective birth cohort study in their first year of life. Physical examination was performed and nasal brush samples were taken during routine visits every 6 months and during an upper respiratory tract infection (URTI) (sick visits). The prevalence of respiratory viral infections in infants with URTI, infants with rhinitis without general malaise and infants without nasal symptoms was studied. Rhinovirus was the most prevalent pathogen during URTI and rhinitis in 0‐ to 2‐year‐old infants (∼40%). During URTI, also respiratory syncytial virus (∼20%) and coronavirus (∼10%) infections were found, which were rarely detected in infants with rhinitis. Surprisingly, in 20% of infants who did not present with nasal symptoms, rhinovirus infections were also detected. During routine visits at 12 months, a higher prevalence of rhinovirus infections was found in infants who attended day‐care compared with those who did not. We did not observe a relation between breast‐feeding or smoking by one or both parents and the prevalence of rhinovirus infections. The parental history of atopy was not related to the prevalence of rhinovirus infection, indicating that the genetic risk of allergic disease does not seem to increase the chance of rhinovirus infections. In conclusion, rhinovirus infection is the most prevalent respiratory viral infection in infants. It may therefore affect the maturation of the immune system and the development of allergic disease considerably.
Url:
DOI: 10.1034/j.1399-3038.2003.00064.x
Affiliations:
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type="abstract" xml:lang="en">Respiratory infections in infancy may protect against developing Th2‐mediated allergic disease (hygiene hypothesis). To estimate the relative contribution of particular viruses to the development of the immune system and allergic disease, we investigated longitudinally the prevalence of respiratory viral infections in infants. One hundred and twenty‐six healthy infants were included in this prospective birth cohort study in their first year of life. Physical examination was performed and nasal brush samples were taken during routine visits every 6 months and during an upper respiratory tract infection (URTI) (sick visits). The prevalence of respiratory viral infections in infants with URTI, infants with rhinitis without general malaise and infants without nasal symptoms was studied. Rhinovirus was the most prevalent pathogen during URTI and rhinitis in 0‐ to 2‐year‐old infants (∼40%). During URTI, also respiratory syncytial virus (∼20%) and coronavirus (∼10%) infections were found, which were rarely detected in infants with rhinitis. Surprisingly, in 20% of infants who did not present with nasal symptoms, rhinovirus infections were also detected. During routine visits at 12 months, a higher prevalence of rhinovirus infections was found in infants who attended day‐care compared with those who did not. We did not observe a relation between breast‐feeding or smoking by one or both parents and the prevalence of rhinovirus infections. The parental history of atopy was not related to the prevalence of rhinovirus infection, indicating that the genetic risk of allergic disease does not seem to increase the chance of rhinovirus infections. In conclusion, rhinovirus infection is the most prevalent respiratory viral infection in infants. It may therefore affect the maturation of the immune system and the development of allergic disease considerably.</div></front></TEI><affiliations><list><country><li>Pays-Bas</li></country><region><li>Hollande-Méridionale</li></region><settlement><li>Rotterdam</li></settlement></list><tree><noCountry><name sortKey="De Waal, Leon" sort="De Waal, Leon" uniqKey="De Waal L" first="Leon" last="De Waal">Leon De Waal</name><name sortKey="Fokkens, Wytske" sort="Fokkens, Wytske" uniqKey="Fokkens W" first="Wytske" last="Fokkens">Wytske Fokkens</name><name sortKey="Koopman, Laurens" sort="Koopman, Laurens" uniqKey="Koopman L" first="Laurens" last="Koopman">Laurens Koopman</name><name sortKey="Neijens, Herman" sort="Neijens, Herman" uniqKey="Neijens H" first="Herman" last="Neijens">Herman Neijens</name><name sortKey="Niesters, Bert" sort="Niesters, Bert" uniqKey="Niesters B" first="Bert" last="Niesters">Bert Niesters</name><name sortKey="Osterhaus, Albert" sort="Osterhaus, Albert" uniqKey="Osterhaus A" first="Albert" last="Osterhaus">Albert Osterhaus</name><name sortKey="Van Benten, Inesz" sort="Van Benten, Inesz" uniqKey="Van Benten I" first="Inesz" last="Van Benten">Inesz Van Benten</name><name sortKey="Van Drunen, Kees" sort="Van Drunen, Kees" uniqKey="Van Drunen K" first="Kees" last="Van Drunen">Kees Van Drunen</name><name sortKey="Van Middelkoop, Barbara" sort="Van Middelkoop, Barbara" uniqKey="Van Middelkoop B" first="Barbara" last="Van Middelkoop">Barbara Van Middelkoop</name></noCountry><country name="Pays-Bas"><region name="Hollande-Méridionale"><name sortKey="Hop, Wim" sort="Hop, Wim" uniqKey="Hop W" first="Wim" last="Hop">Wim Hop</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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